Mikayla Patton belongs to the Oglala Lakota Nation. She was born and raised on the Pine Ridge Reservation near the Blacks Hills of South Dakota. Patton is a multimedia artist now based in Santa Fe, New Mexico. She creates work using alternative printmaking methods; traditional beadwork techniques; papermaking and other mixed media.
In 2019, Patton received her Bachelor of Fine Arts with a focus on printmaking. She received her degree from the Institute of American Indian Art in Santa Fe, New Mexico. Her work was and continues to be shown in galleries and group shows across the United States and the United Kingdom.